Efek Anestesi Infiltrasi terhadap Intensitas Nyeri dan Kadar Interleukin-6 pada Pasca Seksio Sesarea
Abstract
Latar Belakang: Nyeri menjadi permasalahan yang sering dihadapi oleh wanita pascabedah seksio caesarea yang ditandai dengan meningkatnya kadar interluekin-6. Anestesi infiltrasi intraoperatif direkomendasikan pada seksio caesarea elektif sebagai manajemen nyeri.
Tujuan: Menilai efek anestesi infiltrasi bupivakain isobarik 0,25% 50 mg pada luka insisi terhadap intensitas nyeri dan kadar IL-6 pada pascabedah seksio sesarea.
Subjek dan Metode: Penelitian ini menggunakan pendekatan uji klinis acak tersamar ganda. Sampel terdiri atas 3 kelompok yaitu kontrol (B0), diberi anestesi infiltrasi bupivakain sebelum insisi (B1), dan diberi anestesi infiltrasi bupivakain setelah insisi dan sebelum luka ditutup (B2) dengan jumlah sampel masing-masing 8 orang. Data dianalisis menggunakan uji Anova, Kruskal Wallis dan paired t-test dengan tingkat kemaknaan α=0,05.
Hasil: Skor nyeri berbeda signifikan antara kelompok anestesi infiltrasi dengan kontrol pada 8 jam pascabedah (p<0,05). Kadar interleukin-6 berbeda signifikan antara kelompok anestesi infiltrasi dengan kontrol dan antara anestesi infiltrasi sebelum dengan setelah insisi pada 4 jam pasca bedah (p<0,05). Anestesi infiltrasi sebelum insisi menurunkan kadar interleukin-6 lebih besar dibandingkan setelah insisi mulai dari 4 jam pascabedah seksio sesarea.
Simpulan: Pemberian anestesi infiltrasi sebelum insisi dapat menurunkan kadar interleukin-6 lebih cepat dan lebih besar daripada setelah insisi dan juga mengurangi intensitas nyeri
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Jurnal Anestesi Obstetri Indonesia
